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Roles of TolC-Dependent Multidrug Transporters of Escherichia coli in Resistance to β-Lactams

By Kunihiko Nishino, Junko Yamada, Hidetada Hirakawa, Takahiro Hirata and Akihito Yamaguchi


AcrAB exports some β-lactam antibiotics in the periplasm out of cells via an outer-membrane channel, TolC. It has been reported that eight drug transporters in Escherichia coli cooperate with TolC. In this study, the roles of the drug exporters of E. coli in β-lactam resistance were examined. We found that five of five resistance-nodulation-cell division-type drug exporters confer β-lactam antibiotic resistance, while no other drug exporters confer any β-lactam resistance even when they cooperate with TolC

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/AAC.47.9.3030-3033.2003
OAI identifier:
Provided by: PubMed Central
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