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Activity of N-formimidoyl thienamycin and cephalosporins against isolates from nosocomially acquired bacteremia.

By J Gutiérrez-Núñez, P T Harrington and C H Ramirez-Ronda

Abstract

The in vitro activity of N-formimidoyl thienamycin was compared with that of seven beta-lactam agents against bacteremic clinical isolates, including gentamicin-resistant, gram-negative bacilli, Staphylococcus aureus, Staphylococcus epidermidis, streptococci, and enterococci. N-formimidoyl thienamycin was the most active antibiotic against all of the gram-positive cocci studied, with the exception of Staphylococcus epidermidis, and the only agent active against the enterococci. N-formimidoyl thienamycin was less active than some of the other agents against Enterobacteriaceae, except for the strains of Serratia and Citrobacter studied. For Pseudomonas aeruginosa, N-formimidoyl thienamycin was the most active agent (4 micrograms/ml was the lowest concentration that inhibited 90% of the strains tested)

Topics: Research Article
Year: 1982
OAI identifier: oai:pubmedcentral.nih.gov:181925
Provided by: PubMed Central
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