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Combined protective effects on interferon and interferon induction on herpes simplex and ectromelia virus infections in mice.

By J Imanishi, M Matsubara, C J Won, H Nomura and T Kishida


Mouse interferon or the induction of mouse interferon with polyriboinosinic acid-polyribocytidylic acid significantly protected mice against herpes simplex and ectromelia viral infections. When polyriboinosinic acid-polyribocytidylic acid was administered 24 h before herpes simplex or ectromelia viral infection and mouse interferon was administered shortly before and 24 h after infection, a combined protective effect against either herpes simplex or ectromelia viral infection in mice was evident. There was a significant decrease in the mortality rate with the combined treatment as compared either with the rate in group treated with interferon or polyriboinosinic acid-polyribocytidylic acid

Topics: Research Article
Year: 1981
DOI identifier: 10.1128/aac.19.5.922
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Provided by: PubMed Central
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