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Inactivation of ompR Promotes Precocious Swarming and flhDC Expression in Xenorhabdus nematophila

By Dong-jin Kim, Brian Boylan, Nicholas George and Steven Forst

Abstract

The response regulator OmpR is involved in numerous adaptive responses to environmental challenges. The role that OmpR plays in swarming behavior and swarm-cell differentiation in the symbiotic-pathogenic bacterium Xenorhabdus nematophila was examined in this study. Swarming began 4 h sooner in an ompR mutant strain than in wild-type cells. Precocious swarming was correlated with elevated expression of fliC, early flagellation, and cell elongation. The level of flhDC mRNA was elevated during the early period of swarming in the ompR strain relative to the level in the wild type. These findings show that OmpR is involved in the temporal regulation of flhDC expression and flagellum production and demonstrate that this response regulator plays a role in the swarming behavior of X. nematophila

Topics: Molecular Biology of Pathogens
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/JB.185.17.5290-5294.2003
OAI identifier: oai:pubmedcentral.nih.gov:181006
Provided by: PubMed Central
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