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Aztreonam concentration in abdominal tissues and bile.

By R E Condon, L T Friedhoff, C E Edmiston and B Levinson

Abstract

Abdominal tissue, serum, and bile samples were obtained from 37 patients given a single, 2-g intravenous infusion of aztreonam immediately prior to an elective abdominal operation. Samples were obtained at 0 to 6 h after dosing. Mean concentrations in tissues and fluids and specimen/serum rations are reported. Levels in tissue and bile exceeded the reported MICs for 90% of most members of the family Enterobacteriaceae for up to 6 h

Topics: Research Article
Year: 1986
DOI identifier: 10.1128/aac.29.6.1101
OAI identifier: oai:pubmedcentral.nih.gov:180509
Provided by: PubMed Central
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