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An influenza virus inhibitor that acts late in the replication cycle.

By G Antonelli, F Dianzani, D H Coppenhaver, S Baron, P Calandra and G Folchitto


An inhibitor which is active against influenza A virus was found in Neuramide, a complex tissue extract that is used as an anti-herpes zoster virus treatment. Kinetic studies showed that significant inhibition of virus production occurred when the inhibitor was added to infected cultures up to 5 h after virus penetration. Molecular sieving fractionation showed that the antiviral activity was contained in a low-molecular-weight fraction (molecular weight, less than 1,000)

Topics: Research Article
Year: 1986
DOI identifier: 10.1128/aac.29.1.49
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Provided by: PubMed Central
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