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Itraconazole, a new triazole that is orally active in aspergillosis.

By J Van Cutsem, F Van Gerven, M A Van de Ven, M Borgers and P A Janssen


Itraconazole is a new orally active triazole derivative with broad-spectrum antifungal activity. This drug is effective in experimental aspergillosis and possesses in vitro activity against various species and strains of Aspergillus. Morphological destruction of inoculated hyphae and complete inhibition of hyphal outgrowth in culture is obtained from 0.07 micrograms ml-1 (10(-7)M) onward. These properties make itraconazole a likely candidate for clinical evaluation in disseminated aspergillosis

Topics: Research Article
Year: 1984
DOI identifier: 10.1128/aac.26.4.527
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Provided by: PubMed Central
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