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Comparative study of cefoperazone and spectinomycin for treatment of uncomplicated gonorrhea in men.

By E W Hook, F N Judson, M S Verdon, J M Ehret and H H Handsfield

Abstract

Beta-lactamase-negative Neisseria gonorrhoeae infections were treated with single-dose cefoperazone (0.5 or 1.0 g) or spectinomycin (2.0 g). Anogenital infections were cured in 36 (83%) of 43 volunteers given 0.5 g of cefoperazone, 61 of 61 volunteers given 1.0 g of cefoperazone, and 99 of 100 volunteers given spectinomycin. The cefoperazone geometric mean MIC for 242 isolates was 0.028 microgram/ml. Cefoperazone (1.0 g) and spectinomycin (2.0 g) are comparable for the therapy of anogenital gonorrhea in men

Topics: Research Article
Year: 1986
DOI identifier: 10.1128/aac.30.4.619
OAI identifier: oai:pubmedcentral.nih.gov:176494
Provided by: PubMed Central
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