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Leptin: Involvement in the pathophysiology of breast cancer

By Florence Caldefie-Chezet, Virginie Dubois, Laetitia Delort, Adrien Rossary and Marie-Paule VASSON

Abstract

More than one million new cases of breast cancer are diagnosed each year worldwide and more than 400,000 deaths occur due to this pathology. Obesity is a risk factor for postmenopausal breast cancer and the place held by the adipose tissue and secretions (i.e. adipokines) begins to be recognized. Indeed, firstly, plasma adipokine levels, modulated in obesity situation, could have effects "remotely" on mammary carcinogenesis and, secondly, breast cancer cells are surrounded by adipocyte microenvironment, which is probably more important in the case of obesity, and may be locally influenced by it. In this context, leptin appears to be strongly involved in mammary carcinogenesis and may contribute to the angiogenesis process and local pro-inflammatory mechanisms, especially in obese patients for whom increased metastatic potential and risk of mortality are described. (C) 2013 Published by Elsevier Masson SAS

Topics: ACTIVATED PROTEIN-KINASE, MAMMARY-TUMOR GROWTH, WHITE ADIPOSE-TISSUE, DIET-INDUCED OBESITY, SERUM LEPTIN, INSULIN-RESISTANCE, CELL-PROLIFERATION, ESTROGEN-RECEPTOR-ALPHA, CARCINOMA IN-SITU, MESSENGER-RNA, [SDV]Life Sciences [q-bio]
Publisher: 'Elsevier BV'
Year: 2013
DOI identifier: 10.1016/j.ando.2013.03.005
OAI identifier: oai:HAL:hal-02650796v1
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