Location of Repository

Drug combinations for treatment of mice infected with acyclovir-resistant herpes simplex virus.

By R F Schinazi

Abstract

The purpose of this study was to determine whether acyclovir resistance in mice infected with herpes simplex virus could be overcome by using high doses of acyclovir or vidarabine alone or by using a combination of the two drugs. The results indicate that the mice infected intracerebrally were refractory to acyclovir alone but responded to vidarabine or a combination of vidarabine and acyclovir. These observations have major implications for the clinical management of severe herpetic infections, particularly if attempts are to be made to devise means of circumventing drug resistance

Topics: Research Article
Year: 1987
OAI identifier: oai:pubmedcentral.nih.gov:174758
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles


To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.