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Berberine derivatives as antileishmanial drugs.

By J L Vennerstrom, J K Lovelace, V B Waits, W L Hanson and D L Klayman

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (greater than 50% suppression of lesion size) against L. braziliensis panamensis

Topics: Research Article
Year: 1990
OAI identifier: oai:pubmedcentral.nih.gov:171721
Provided by: PubMed Central
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