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Nucleoporin p62 Antibodies in a Case of Mixed Connective Tissue Disease

By Doris M. Kraemer, Michael R. Kraus, Christian Kneitz and Hans-Peter Tony


Mixed connective tissue disease is an overlap syndrome characterized by features of different systemic autoimmune diseases and a high titer of U1-snRNP antibodies. We examine here the autoantibodies to nucleoporin p62 in a severe case of mixed connective tissue disease in a young male patient. Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders

Topics: Immune-Mediated Responses and Disorders
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/CDLI.10.2.329-331.2003
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Provided by: PubMed Central
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