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Additional Targets of the Bacillus subtilis Global Regulator CodY Identified by Chromatin Immunoprecipitation and Genome-Wide Transcript Analysis

By Virginie Molle, Yoshiko Nakaura, Robert P. Shivers, Hirotake Yamaguchi, Richard Losick, Yasutaro Fujita and Abraham L. Sonenshein


Additional targets of CodY, a GTP-activated repressor of early stationary-phase genes in Bacillus subtilis, were identified by combining chromatin immunoprecipitation, DNA microarray hybridization, and gel mobility shift assays. The direct targets of CodY newly identified by this approach included regulatory genes for sporulation, genes that are likely to encode transporters for amino acids and sugars, and the genes for biosynthesis of branched-chain amino acids

Topics: Gene Regulation
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/JB.185.6.1911-1922.2003
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Provided by: PubMed Central
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