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Sequence Polymorphism of the 16S rRNA Gene of Vibrio vulnificus Is a Possible Indicator of Strain Virulence

By William B. Nilsson, Rohinee N. Paranjype, Angelo DePaola and Mark S. Strom


Vibrio vulnificus exhibits considerable strain-to-strain variation in virulence. Attempts to associate phenotypic or genotypic characteristics with strain virulence have been largely unsuccessful. Based on a 17-nucleotide difference throughout the sequence of the small subunit 16S rRNA gene, there are two major groups of V. vulnificus designated types A and B. In a survey of the 16S rRNA genotype in 67 V. vulnificus human clinical and nonclinical strains, we determined that the majority of nonclinical isolates are type A (31 of 33) and that there is a statistically significant association between the type B genotype and human clinical strains (26 of 34)

Topics: Bacteriology
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/JCM.41.1.442-446.2003
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Provided by: PubMed Central
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