oaioai:dspace.xmu.edu.cn:2288/169978

Persistence of antibodies induced by natural hepatitis E virus infection with or without hepatitis E vaccine boosting and the seroprotective antibody level of hepatitis E

Abstract

自然感染获得的免疫力对于预防HEV的新发感染发挥着重要的作用,但自然感染获得的HEV抗体的衰减规律和持续时间尚不清楚。本研究基于戊型肝炎疫苗Ⅲ期临床试验及其延续性监测中所采集的免后5.5年内的系列血清抗-HEVIgG数据,将其分成三个数据集进行免疫持久性分析,数据集A为对照组基线HEVIgG阳性人群,7m及之后至少一个时间点有抗-HEVIgG定量检测结果,共纳入2242人;数据集B为对照组7m内HEV新发感染人群,7m之后至少一个时间点有抗-HEVIgG定量检测结果,共纳入60人;数据集C为疫苗组基线HEVIgG阳性戊肝疫苗免疫人群,7m之后至少一个时间点有抗-HEVIgG定量检测结果,共纳入...Naturally acquired anti-hepatitis E virus (HEV) immunity can protect against new HEV infection, although the long-term persistence of natural anti-HEV IgG remains unknown. We analyzed the serology data of a phase III clinical trial of the HEV 239 vaccine during a 67 month follow-up period and predicted long-term persistence with mathematical models. The serology data was grouped into three data se...学位:博士后院系专业:生命科学学院_生物学学号:201517006

Similar works

Full text

thumbnail-image

Xiamen University Institutional Repository

Provided a free PDF
oaioai:dspace.xmu.edu.cn:2288/169978Last time updated on 6/10/2020View original full text link

This paper was published in Xiamen University Institutional Repository.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.