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红树林共生真菌Paecilomyces sp· Tree 1-7代谢产物的研究

By 温露, 林永成, 赵丽冰, 佘志刚, 蔡小铃 and 郑忠辉


用硅胶柱色谱及重结晶等方法,并根据理化性质和光谱数据从一株红树林共生真菌Paecilomycessp.Tree 1-7中分离鉴定了四个化合物,分别为secalon ic ac id A(1),tenellic ac id A(2),大黄素(3),大黄酚(4)。并首次对化合物1和2进行了抗人的肝癌细胞hepG2的活性测试。结果显示,化合物1有很强的抗肿瘤活性,IC50=2.0μg/m l,化合物2的抗肿瘤活性IC50=62.1μg/m l

Topics: 红树林, Paecilomycessp.Tree1-7, 代谢产物
Year: 2006
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