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A simple, reproducible method for monitoring the treatment of tumours using dynamic contrast-enhanced MR imaging

By Bruno Morgan (594445), J. F. Utting (7682981), A. Higginson (7682984), A. L. Thomas (7642964), William Patrick P. Steward (7682987) and Mark Andrew Horsfield (7682990)

Abstract

Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respiratory motion. Data from phantom studies and a reproducibility study in solid human tumours are presented. The reproducibility study showed a coefficient of variation (CoV) of 19.1% for K(trans) and 15.8% for the initial area under the contrast enhancement curve (IAUC). This was improved to 16 and 13.9% if tumours of diameter less than 3 cm were excluded. The individual repeatability (the range within which individual measurements are expected to fall) was 30.6% for K(trans) and 26.5% for IAUC for tumours greater than 3 cm diameter. This approach to DCE-MRI image acquisition can be performed with standard clinical scanners, and data analysis is straightforward. For treatment trials with 10 patients in a cohort, the CoV implies that the method would be sensitive to a treatment effect of greater than 18%. The individual repeatability is well inside the 40% change shown to be important in clinical studies using this DCE-MRI technique

Topics: Uncategorized, Angiogenesis Inhibitors, Area Under Curve, Colorectal Neoplasms, Contrast Media, Drug Monitoring, Humans, Image Processing, Computer-Assisted, Liver Neoplasms, Lung Neoplasms, Magnetic Resonance Imaging, Phantoms, Imaging, Phthalazines, Pyridines, Receptors, Vascular Endothelial Growth Factor, Reproducibility of Results
Year: 2006
OAI identifier: oai:figshare.com:article/10168130
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