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We develop a general framework for the discussion of detailed balance and analyse its microscopic background. We find that there should be two additions to the well-known T- or PT-invariance of the microscopic laws of motion: 1. Equilibrium should not spontaneously break the relevant T- or PT-symmetry. 2. The macroscopic processes should be microscopically distinguishable to guarantee persistence of detailed balance in the model reduction from micro- to macrokinetics. We briefly discuss examples of the violation of these rules and the corresponding violation of detailed balance
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