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Fibrinogen Binding to Intercellular Adhesion Molecule 1: Implications for Plasmodium falciparum Adhesion

By Carolyn Gray and Alister Craig

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is an endothelial cell adhesion molecule implicated in cerebral malaria. We investigated whether fibrinogen affects Plasmodium falciparum binding to ICAM-1, as the ICAM-1 binding sites of P. falciparum and fibrinogen overlap. We show that fibrinogen dramatically reduces P. falciparum adhesion to ICAM-1 under flow conditions

Topics: Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/IAI.70.7.3962-3964.2002
OAI identifier: oai:pubmedcentral.nih.gov:128049
Provided by: PubMed Central
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