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Penetration of Rifampin through Staphylococcus epidermidis Biofilms

By Zhilan Zheng and Philip S. Stewart


Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/AAC.46.3.900-903.2002
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Provided by: PubMed Central
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