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Comparative Pharmacodynamics of Three Newer Fluoroquinolones versus Six Strains of Staphylococci in an In Vitro Model under Aerobic and Anaerobic Conditions

By David H. Wright, Brent W. Gunderson, Laurie B. Hovde, Gigi H. Ross, Khalid H. Ibrahim and John C. Rotschafer


Six strains of staphylococci were exposed to levofloxacin, moxifloxacin, or trovafloxacin in an in vitro pharmacodynamic model under both aerobic and anaerobic conditions. Each agent demonstrated a rapid 3-log(10) kill versus susceptible isolates regardless of condition. Against clinical isolates with reduced susceptibility, regrowth occurred by 24 h and was frequently associated with further increases in MICs

Topics: Experimental Therapeutics
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/AAC.46.5.1561-1563.2002
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Provided by: PubMed Central
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