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mar Operon Involved in Multidrug Resistance of Enterobacter aerogenes

By Renaud Chollet, Claude Bollet, Jacqueline Chevalier, Monique Malléa, Jean-Marie Pagès and Anne Davin-Regli

Abstract

We determined the sequence of the entire marRAB operon in Enterobacter aerogenes. It is functionally and structurally analogous to the Escherichia coli operon. The overexpression of E. aerogenes MarA induces a multidrug resistance phenotype in a susceptible strain, demonstrated by a noticeable resistance to various antibiotics, a decrease in immunodetected porins, and active efflux of norfloxacin

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/AAC.46.4.1093-1097.2002
OAI identifier: oai:pubmedcentral.nih.gov:127096
Provided by: PubMed Central
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