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Sporadic Emergence of Klebsiella pneumoniae Strains Resistant to Cefepime and Cefpirome in Greek Hospitals

By L. S. Tzouvelekis, E. Tzelepi, E. Prinarakis, M. Gazouli, A. Katrahoura, P. Giakkoupi, O. Paniara and N. J. Legakis

Abstract

The sporadic emergence of Klebsiella pneumoniae strains resistant to cefepime and cefpirome was observed in Greek hospitals during 1996. Examination of six epidemiologically distinct strains and clones selected in vitro provided indications that resistance is due to the cooperation of decreased outer membrane permeability and hydrolysis of the cephalosporins by SHV-5 β-lactamase, which was produced in large amounts

Topics: Bacteriology
Publisher: American Society for Microbiology
Year: 1998
OAI identifier: oai:pubmedcentral.nih.gov:124849
Provided by: PubMed Central
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