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NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1

By Rami Yaka, Claire Thornton, Alicia J. Vagts, Khanhky Phamluong, Antonello Bonci and Dorit Ron

Abstract

Phosphorylation regulates the function of ligand-gated ion channels such as the N-methyl d-aspartate (NMDA) receptor. Here we report a mechanism for modulation of the phosphorylation state and function of the NMDA receptor via an inhibitory scaffolding protein, RACK1. We found that RACK1 binds both the NR2B subunit of the NMDA receptor and the nonreceptor protein tyrosine kinase, Fyn. RACK1 inhibits Fyn phosphorylation of NR2B and decreases NMDA receptor-mediated currents in CA1 hippocampal slices. Peptides that disrupt the interactions between RACK1, NR2B, and Fyn induce phosphorylation and potentiate NMDA receptor-mediated currents. Therefore, RACK1 is a regulator of NMDA receptor function and may play a role in synaptic plasticity, addiction, learning, and memory

Topics: Biological Sciences
Publisher: National Academy of Sciences
Year: 2002
DOI identifier: 10.1073/pnas.062046299
OAI identifier: oai:pubmedcentral.nih.gov:122836
Provided by: PubMed Central
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