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Bacteroides ovatus as the Predominant Commensal Intestinal Microbe Causing a Systemic Antibody Response in Inflammatory Bowel Disease

By Shin Saitoh, Satoshi Noda, Yuji Aiba, Atsushi Takagi, Mitsuo Sakamoto, Yoshimi Benno and Yasuhiro Koga

Abstract

To clarify what bacterial species of commensal intestinal microbes are recognized as the antigens that induce a serum antibody response in patients with inflammatory bowel disease (IBD), 72 subjects consisting of 12 Crohn’s disease patients, 30 ulcerative colitis patients, and 30 healthy volunteers were examined for their titers of serum antibody to these intestinal bacteria. In IBD patients, as a result, significant elevations of both the immunoglobulin G (IgG) and IgA titers to Bacteroides ovatus were found. Immunoblotting showed that a definite 19.5-kDa band of B. ovatus was bound to the serum antibody raised in IBD patients. It was thus concluded that B. ovatus causes serum antibody responses in IBD patients, and a 19.5-kDa molecule of this bacterium appears to be the responsible antigen, although the role of this event in pathogenesis remains unclear

Topics: Antibodies and Mediators of Immunity
Publisher: American Society for Microbiology
Year: 2002
DOI identifier: 10.1128/CDLI.9.1.54-59.2002
OAI identifier: oai:pubmedcentral.nih.gov:119885
Provided by: PubMed Central
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