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Infrequent Occurrence of Natural Mutations in the pp65(495–503) Epitope Sequence Presented by the HLA A∗0201 Allele among Human Cytomegalovirus Isolates

By John A. Zaia, Ghislaine Gallez-Hawkins, Xiuli Li, Zhi-Qiang Yao, Norma Lomeli, Karen Molinder, Corinna La Rosa and Don J. Diamond


To determine if mutations of an immunodominant HLA-restricted cytomegalovirus (CMV) peptide sequence occur in nature, the sequence corresponding to the HLA A∗0201-specific peptide CMVpp65(495–503) was determined in 50 human CMV isolates. Rare mutations were detected; 6 of 50 were silent mutations at the amino terminus of the peptide, while 3 of 50 were mutations of the native methionine residue to isoleucine (M499I). The observed M499I mutation in three isolates decreased cytolytic targeting

Topics: Pathogenesis and Immunity
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/JVI.75.5.2472-2474.2001
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Provided by: PubMed Central
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