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Measles Virus Induces Functional TRAIL Production by Human Dendritic Cells

By Pierre-Olivier Vidalain, Olga Azocar, Barbara Lamouille, Anne Astier, Chantal Rabourdin-Combe and Christine Servet-Delprat


Measles virus infection induces a profound immunosuppression that can lead to serious secondary infections. Here we demonstrate that measles virus induces tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mRNA and protein expression in human monocyte-derived dendritic cells. Moreover, measles virus-infected dendritic cells are shown to be cytotoxic via the TRAIL pathway

Topics: Virus-Cell Interactions
Publisher: American Society for Microbiology
Year: 2000
OAI identifier: oai:pubmedcentral.nih.gov:111571
Provided by: PubMed Central
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