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Comparative Analysis of Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Activity in Serum and Lethality in Mice and Rabbits Pretreated with the Staphylococcal Superantigen Toxic Shock Syndrome Toxin 1

By Martin M. Dinges and Patrick M. Schlievert

Abstract

Host susceptibility to lipopolysaccharide (LPS) is correlated with the levels of circulating tumor necrosis factor alpha (TNF-α) that develop in response to circulating LPS. Mice are resistant, relative to rabbits, to the lethal effects of LPS. This study indicates that mice and rabbits are equally sensitive to the lethal effects of circulating TNF-α but that mice are more resistant than rabbits to the induction of circulating TNF-α by LPS

Topics: Host Response and Inflammation
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.11.7169-7172.2001
OAI identifier: oai:pubmedcentral.nih.gov:100117
Provided by: PubMed Central
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