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Effects of Exogenous Interleukin-6 during Pseudomonas aeruginosa Corneal Infection

By Nerida Cole, Mark Krockenberger, Shisan Bao, Kenneth W. Beagley, Alan J. Husband and Mark Willcox


Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection

Topics: Microbial Immunity and Vaccines
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.6.4116-4119.2001
OAI identifier:
Provided by: PubMed Central
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