Skip to main content
Article thumbnail
Location of Repository

Effects of Exogenous Interleukin-6 during Pseudomonas aeruginosa Corneal Infection

By Nerida Cole, Mark Krockenberger, Shisan Bao, Kenneth W. Beagley, Alan J. Husband and Mark Willcox

Abstract

Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection

Topics: Microbial Immunity and Vaccines
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/IAI.69.6.4116-4119.2001
OAI identifier: oai:pubmedcentral.nih.gov:98477
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://dx.doi.org/10.1128/IAI.... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.