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Construction of Urease-Negative Mutants of Yersinia enterocolitica Serotypes O:3 and O:8: Role of Urease in Virulence and Arthritogenicity

By Christel Gripenberg-Lerche, Lijuan Zhang, Päivi Ahtonen, Paavo Toivanen and Mikael Skurnik


Yersinia enterocolitica serotype O:3 and O:8 urease-negative mutants unable to express the 19-kDa β subunit of urease were constructed and tested for virulence and arthritogenicity. Our results indicate that urease is needed for full virulence in oral infections and that it is not an arthritogenic factor in the rat model

Topics: Bacterial Infections
Publisher: American Society for Microbiology
Year: 2000
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Provided by: PubMed Central
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