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Type III Secretion-Dependent Hemolytic Activity of Enteropathogenic Escherichia coli

By Jonathan Warawa, B. Brett Finlay and Brendan Kenny

Abstract

Enteropathogenic Escherichia coli (EPEC) was found to exhibit a type III secretion-dependent, contact-mediated, hemolytic activity requiring the EspA, EspB, and EspD secreted proteins. EspB and EspD display homology to pore-forming molecules. Our data suggest a mechanism to explain the requirement for all three Esp proteins in the transfer of EPEC proteins, such as Tir, into target cells

Topics: Molecular and Cellular Pathogenesis
Publisher: American Society for Microbiology
Year: 1999
OAI identifier: oai:pubmedcentral.nih.gov:96921
Provided by: PubMed Central
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