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Tumor Necrosis Factor (TNF) and a TNF-Mimetic Peptide Modulate the Granulomatous Response to Mycobacterium bovis BCG Infection In Vivo

By D. R. Roach, H. Briscoe, K. Baumgart, D. A. Rathjen and W. J. Britton


Tumor necrosis factor (TNF) is a critical mediator in the immune response to mycobacteria, particularly in the formation and maintenance of granulomas. Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mimetic peptide (TNF70–80) altered the number and cellular composition of granulomas. This change was associated with a moderate decrease in the bacterial burden

Topics: Microbial Immunity and Vaccines
Publisher: American Society for Microbiology
Year: 1999
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Provided by: PubMed Central
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