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Late Hematogenous Infection of Subcutaneous Implants in Rats

By B. Gottenbos, F. Klatter, H. C. Van Der Mei, H. J. Busscher and P. Nieuwenhuis


Late biomaterial-centered infection is a major complication associated with the use of biomaterial implants. In this study biomaterials that had been implanted subcutaneously in rats were hematogenously challenged with bacteria 4 weeks after implantation. Bacteria were spread either by intravenous injection or by stimulation of bacterial translocation. It was found that none of the biomaterials was infected by hematogenous spread, whereas 5% of the implants were infected by perioperative contamination. We conclude that late hematogenous infection of subcutaneous biomaterials does not occur in the rat. For humans as well, there are growing doubts whether implants actually become infected through hematogenous routes; it is thought that late infections may be caused by delayed appearance of perioperatively introduced bacteria

Topics: Experimental Clinical Investigation
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/CDLI.8.5.980-983.2001
OAI identifier:
Provided by: PubMed Central
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