Increased Levels of ɛ and γ Isoforms of 14-3-3
 Proteins in Cerebrospinal Fluid in Patients with
 Creutzfeldt-Jakob Disease

Takahashi, Hidehiro; Iwata, Toshinari; Kitagawa, Yoshinori; Takahashi, Reisuke H.; Sato, Yuko; Wakabayashi, Hideki; Takashima, Miwa; Kido, Hiroshi; Nagashima, Kazuo; Kenney, Kimbra; Gibbs, Clarence J.; Kurata, Takeshi

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Increased Levels of ɛ and γ Isoforms of 14-3-3 Proteins in Cerebrospinal Fluid in Patients with Creutzfeldt-Jakob Disease

By Hidehiro Takahashi, Toshinari Iwata, Yoshinori Kitagawa, Reisuke H. Takahashi, Yuko Sato, Hideki Wakabayashi, Miwa Takashima, Hiroshi Kido, Kazuo Nagashima, Kimbra Kenney, Clarence J. Gibbs and Takeshi Kurata

Abstract

We established four hybridoma cell lines producing monoclonal antibodies (MAbs) against 14-3-3 proteins. Immunoblot analysis revealed that ɛ and γ isoforms were specifically increased in premortem cerebrospinal fluid samples from patients with sporadic Creutzfeldt-Jakob disease. Furthermore, dot immunoblot analysis showed that MAbs were more specific for native antigen than polyclonal antibodies were

Topics: Article

Publisher: American Society for Microbiology

Year: 1999

OAI identifier: oai:pubmedcentral.nih.gov:95810

Provided by: PubMed Central

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Increased Levels of ɛ and γ Isoforms of 14-3-3 Proteins in Cerebrospinal Fluid in Patients with Creutzfeldt-Jakob Disease

Abstract

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