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Increased Levels of ɛ and γ Isoforms of 14-3-3 Proteins in Cerebrospinal Fluid in Patients with Creutzfeldt-Jakob Disease

By Hidehiro Takahashi, Toshinari Iwata, Yoshinori Kitagawa, Reisuke H. Takahashi, Yuko Sato, Hideki Wakabayashi, Miwa Takashima, Hiroshi Kido, Kazuo Nagashima, Kimbra Kenney, Clarence J. Gibbs and Takeshi Kurata


We established four hybridoma cell lines producing monoclonal antibodies (MAbs) against 14-3-3 proteins. Immunoblot analysis revealed that ɛ and γ isoforms were specifically increased in premortem cerebrospinal fluid samples from patients with sporadic Creutzfeldt-Jakob disease. Furthermore, dot immunoblot analysis showed that MAbs were more specific for native antigen than polyclonal antibodies were

Topics: Article
Publisher: American Society for Microbiology
Year: 1999
OAI identifier: oai:pubmedcentral.nih.gov:95810
Provided by: PubMed Central
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