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Restricted Isotypic Antibody Reactivity to Hepatitis C Virus Synthetic Peptides in Immunocompromised Patients

By Marisol Devesa, Arlette de Saez, Graciela León, Firelei Sirit, Clarisa Cosson, Henry Bermúdez, Ferdinando Liprandi, Oscar Noya and Flor H. Pujol


An enzyme immunoassay based on three synthetic peptides from the core, NS4, and NS5 regions of hepatitis C virus allowed the detection of antibodies in 100% of immunocompetent infected patients and in 91% of immunocompromised patients (hemodialysis and hemophiliac patients). Immune impairment seemed to restrict the spectrum of antibody isotypes reacting to the core peptide

Topics: Article
Publisher: American Society for Microbiology
Year: 1999
OAI identifier:
Provided by: PubMed Central
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