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Cholic Acid Is Accumulated Spontaneously, Driven by Membrane ΔpH, in Many Lactobacilli

By Peter Kurdi, Hendrik W. van Veen, Hiroshi Tanaka, Igor Mierau, Wil N. Konings, Gerald W. Tannock, Fusao Tomita and Atsushi Yokota


Many lactobacilli from various origins were found to apparently lack cholic acid extrusion activity. Cholic acid was accumulated spontaneously, driven by the transmembrane proton gradient. Accumulation is a newly identified kind of interaction between intestinal microbes and unconjugated bile acids and is different from extrusion and modification, which have been described previously

Topics: Physiology and Metabolism
Publisher: American Society for Microbiology
Year: 2000
OAI identifier: oai:pubmedcentral.nih.gov:94804
Provided by: PubMed Central
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