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Gradual Alterations in Cell Wall Structure and Metabolism in Vancomycin-Resistant Mutants of Staphylococcus aureus

By Krzysztof Sieradzki and Alexander Tomasz


In five vancomycin-resistant laboratory step mutants selected from the highly and homogeneously methicillin-resistant Staphylococcus aureus strain COL (MIC of methicillin, 800 μg/ml; MIC of vancomycin, 1.5 μg/ml), the gradually increasing levels of resistance to vancomycin were accompanied by parallel decreases in the levels of methicillin resistance and abnormalities in cell wall metabolism. The latter included a gradual reduction in the proportion of highly cross-linked muropeptide species in peptidoglycan, down-regulation of the production of penicillin-binding protein 2A (PBP2A) and PBP4, and hypersensitivity to β-lactam antibiotics each with a relatively selective affinity for the various staphylococcal PBPs; the PBP2-specific inhibitor ceftizoxime was particularly effective

Topics: Cell Surfaces
Publisher: American Society for Microbiology
Year: 1999
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Provided by: PubMed Central
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