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Antisense Silencing of the creA Gene in Aspergillus nidulans

By L. Fernando Bautista, Alexei Aleksenko, Morten Hentzer, Anne Santerre-Henriksen and Jens Nielsen


Antisense expression of a portion of the gene encoding the major carbon catabolite repressor CREA in Aspergillus nidulans resulted in a substantial increase in the levels of glucose-repressible enzymes, both endogenous and heterologous, in the presence of glucose. The derepression effect was approximately one-half of that achieved in a null creA mutant. Unlike results for that mutant, however, growth parameters and colony morphology in the antisense transformants were not affected

Topics: Mycology
Publisher: American Society for Microbiology
Year: 2000
OAI identifier: oai:pubmedcentral.nih.gov:92348
Provided by: PubMed Central
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