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Effect of Catalase on Hydrogen Peroxide Penetration into Pseudomonas aeruginosa Biofilms

By Philip S. Stewart, Frank Roe, Joanna Rayner, James G. Elkins, Zbigniew Lewandowski, Urs A. Ochsner and Daniel J. Hassett

Abstract

The penetration of hydrogen peroxide into biofilms formed by wild-type and catalase-deficient Pseudomonas aeruginosa strains was measured using microelectrodes. A flowing stream of hydrogen peroxide (50 mM, 1 h) was unable to penetrate or kill wild-type biofilms but did penetrate and partially kill biofilms formed by an isogenic strain in which the katA gene was knocked out. Catalase protects aggregated bacteria by preventing full penetration of hydrogen peroxide into the biofilm

Topics: Physiology and Biotechnology
Publisher: American Society for Microbiology
Year: 2000
OAI identifier: oai:pubmedcentral.nih.gov:91906
Provided by: PubMed Central
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