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In Vitro Susceptibility of Coxiella burnetii to Linezolid in Comparison with Its Susceptibilities to Quinolones, Doxycycline, and Clarithromycin

By Achilleas Gikas, Ioanna Spyridaki, Efstathia Scoulica, Anna Psaroulaki and Yannis Tselentis

Abstract

The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of linezolid and clarithromycin ranged from 2 to 4 μg/ml; those of doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 μg/ml; those of pefloxacin ranged from 1 to 4 μg/ml; and those of ciprofloxacin ranged from 4 to 8 μg/ml. Linezolid was effective in controlling intracellular parasites in cultures of Vero cells infected by C. burnetii. No bactericidal activity by linezolid was obtained against C. burnetii at 8 μg/ml

Topics: Susceptibility
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/AAC.45.11.3276-3278.2001
OAI identifier: oai:pubmedcentral.nih.gov:90826
Provided by: PubMed Central
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