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Susceptibilities of Oral Bacteria and Yeast to Mammalian Cathelicidins

By Janet M. Guthmiller, Kaaren G. Vargas, Rupasree Srikantha, Lori L. Schomberg, Paula L. Weistroffer, Paul B. McCray and Brian F. Tack

Abstract

The effects of cathelicidins against oral bacteria and clinically important oral yeasts are not known. We tested the susceptibilities of Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Streptococcus sanguis, Candida krusei, Candida tropicalis and Candida albicans to the following cathelicidins: FALL39, SMAP29, and CAP18. SMAP29 and CAP18 were antimicrobial, whereas FALL39 did not exhibit antimicrobial activity. Future studies are needed to determine the potential use of these antimicrobial peptides in prevention and treatment of oral infections

Topics: Susceptibility
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/AAC.45.11.3216-3219.2001
OAI identifier: oai:pubmedcentral.nih.gov:90809
Provided by: PubMed Central
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