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In Vitro Activities of ABT-773, a New Ketolide, against Aerobic and Anaerobic Pathogens Isolated from Antral Sinus Puncture Specimens from Patients with Sinusitis

By Ellie J. C. Goldstein, Georg Conrads, Diane M. Citron, C. Vreni Merriam, Yumi Warren and Kerin Tyrrell


The comparative in vitro activities of ABT-773 against 207 aerobic and 162 anaerobic antral sinus puncture isolates showed that erythromycin-resistant pneumococcal strains were susceptible to ABT-773 (≤0.125 μg/ml); the MIC at which 90% of the isolates tested were inhibited for Haemophilus influenzae and other Haemophilus spp. was 4 μg/ml; and all Moraxella spp. and beta-lactamase-producing Prevotella species strains were inhibited by ≤0.125 μg/ml. Among the anaerobes tested, only fusobacteria (45%) required ≥4 μg of ABT-773/ml for inhibition. ABT-773 may offer a therapeutic alternative for sinus infections

Topics: Susceptibility
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/AAC.45.8.2363-2367.2001
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Provided by: PubMed Central
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