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Serotype 19F Multiresistant Pneumococcal Clone Harboring Two Erythromycin Resistance Determinants [erm(B) and mef(A)] in South Africa

By Lesley McGee, Keith P. Klugman, Avril Wasas, Thora Capper and Adrian Brink


One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of ≥0.5 μg/ml) from five laboratories serving the private sector in South Africa were analyzed for the genes encoding resistance to macrolides. Sixty-seven ERSP strains (56.8%) contained the erm(B) gene, and 15 isolates (12.7%) contained the mef(A) gene. Thirty-six isolates (30.5%) harbored both the erm(B) and mef(A) genes and were highly resistant to erythromycin and clindamycin. DNA fingerprinting by BOX-PCR and pulsed-field gel electrophoresis identified 83% of these strains as belonging to a single multiresistant serotype 19F clone

Topics: Mechanisms of Resistance
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/AAC.45.5.1595-1598.2001
OAI identifier: oai:pubmedcentral.nih.gov:90516
Provided by: PubMed Central
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