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Inhibitory Activities of Lansoprazole against Respiration in Helicobacter pylori

By Kumiko Nagata, Nobuhito Sone and Toshihide Tamura

Abstract

Lansoprazole and its derivative AG-1789 dose-dependently inhibited cellular respiration by an endogenous substrate and decreased the ATP level in Helicobacter pylori cells. The inhibitory action of lansoprazole and AG-1789 against respiration was specific to substrates such as pyruvate and α-ketoglutarate and similar to the inhibitory action of rotenone, which is an inhibitor for the mitochondrial respiratory chain. Growth inhibition by lansoprazole and AG-1789 as well as by rotenone was augmented at high oxygen concentrations under atmospheric conditions. Since the 50% inhibitory concentrations of these compounds for the respiration were close to their MICs for H. pylori growth, the growth inhibition might be due to respiratory inhibition by these compounds

Topics: Mechanisms of Action: Physiological Effects
Publisher: American Society for Microbiology
Year: 2001
DOI identifier: 10.1128/AAC.45.5.1522-1527.2001
OAI identifier: oai:pubmedcentral.nih.gov:90499
Provided by: PubMed Central
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