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Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

By C A Mallick-Wood, W Pao, A M Cheng, J M Lewis, S Kulkarni, J B Bolen, B Rowley, R E Tigelaar, T Pawson and A C Hayday

Abstract

Chimeric mice in which lymphocytes are deficient in the Syk tyrosine kinase have been created. Compared with Syk-positive controls, mice with Syk -/- lymphocytes display substantial depletion of intraepithelial gamma delta T cells in the skin and gut, with developmental arrest occurring after antigen receptor gene rearrangement. In this dependence on Syk, subsets of intraepithelial gamma delta T cells are similar to B cells, but distinct from splenic gamma delta T cells that develop and expand in Syk-deficient mice. The characteristic associations of certain T-cell receptor V gamma/V delta gene rearrangements with specific epithelia are also disrupted by Syk deficiency

Topics: Research Article
Year: 1996
DOI identifier: 10.1073/pnas.93.18.9704
OAI identifier: oai:pubmedcentral.nih.gov:38493
Provided by: PubMed Central
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