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A General RNA-Binding Protein Complex That Includes the Cytoskeleton-associated Protein MAP 1A

By Christopher DeFranco, Marina E. Chicurel and Huntington Potter


Association of mRNA with the cytoskeleton represents a fundamental aspect of RNA physiology likely involved in mRNA transport, anchoring, translation, and turnover. We report the initial characterization of a protein complex that binds RNA in a sequence-independent but size-dependent manner in vitro. The complex includes a ∼160-kDa protein that is bound directly to mRNA and that appears to be either identical or highly related to a ∼1600-kDa protein that binds directly to mRNA in vivo. In addition, the microtubule-associated protein, MAP 1A, a cytoskeletal associated protein is a component of this complex. We suggest that the general attachment of mRNA to the cytoskeleton may be mediated, in part, through the formation of this ribonucleoprotein complex

Topics: Article
Publisher: The American Society for Cell Biology
Year: 1998
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Provided by: PubMed Central
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