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Is the molten globule a third phase of proteins?

By Vijay S. Pande and Daniel S. Rokhsar


The equilibrium properties of proteins are studied by Monte Carlo simulation of two simplified models of protein-like heteropolymers. These models emphasize the polymeric entropy of the fluctuating polypeptide chain. Our calculations suggest a generic phase diagram that contains a thermodynamically distinct “molten globule” state in addition to a rigid native state and a nontrivial unfolded state. The roles of side-chain packing and loop entropy are discussed

Topics: Biological Sciences
Publisher: The National Academy of Sciences
Year: 1998
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Provided by: PubMed Central
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