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Cockroach diuretic hormones: Characterization of a calcitonin-like peptide in insects

By Kenji Furuya, Richard J. Milchak, Kathleen M. Schegg, Jinrui Zhang, Stephen S. Tobe, Geoffrey M. Coast and David A. Schooley


Insect diuretic hormones are crucial for control of water balance. We isolated from the cockroach Diploptera punctata two diuretic hormones (DH), Dippu-DH(31) and Dippu-DH(46), which increase cAMP production and fluid secretion in Malpighian tubules of several insect species. Dippu-DH(31) and -DH(46) contain 31 and 46 amino acids, respectively. Dippu-DH(46) belongs to the corticotropin-releasing factor (CRF)-like insect DH family, whereas Dippu-DH(31) has little sequence similarity to the CRF-like DH, but is similar to the calcitonin family. Dippu-DH(46) and -DH(31) have synergistic effects in D. punctata but have only additive effects in Locusta migratoria. Dippu-DH(31) represents a distinct type of insect DH with actions that differ from those of previously identified insect peptides with diuretic activity

Topics: Biological Sciences
Publisher: National Academy of Sciences
Year: 2000
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Provided by: PubMed Central
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