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Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor α

By Akira Orimo, Satoshi Inoue, Osamu Minowa, Nobuko Tominaga, Yasuhiro Tomioka, Miyuki Sato, Junko Kuno, Hisahiko Hiroi, Yoshihiko Shimizu, Masami Suzuki, Tetsuo Noda and Masami Muramatsu

Abstract

The biological roles of estrogen-responsive finger protein (efp) in vivo were evaluated in mice carrying a loss-of-function mutation in efp by gene-targeted mutagenesis. Although efp homozygous mice were viable and fertile in both sexes, the uterus that expressed abundant estrogen receptor α exhibited significant underdevelopment. When the ovariectomized homozygotes were subjected to 17β-estradiol treatment, they showed remarkably attenuated responses to estrogen, as exemplified by decreased interstitial water imbibition and retarded endometrial cell increase, at least, attributable to the lower ratio of G1 to S-phase progression in epithelial cells. These results suggest that efp is essential for the normal estrogen-induced cell proliferation and uterine swelling as one of the direct targets of estrogen receptor α

Topics: Biological Sciences
Publisher: The National Academy of Sciences
Year: 1999
OAI identifier: oai:pubmedcentral.nih.gov:18406
Provided by: PubMed Central
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