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Localization of a peripheral membrane protein: Gβγ targets GαZ

By C. Simone Fishburn, Sonia K. Pollitt and Henry R. Bourne


To explore the relative roles of protein-binding partners vs. lipid modifications in controlling membrane targeting of a typical peripheral membrane protein, Gαz, we directed its binding partner, βγ, to mislocalize on mitochondria. Mislocalized βγ directed wild-type Gαz and a palmitate-lacking Gαz mutant to mitochondria but did not alter localization of a Gαz mutant lacking both myristate and palmitate. Thus, in this paradigm, a protein–protein interaction controls targeting of a peripheral membrane protein to the proper compartment, whereas lipid modifications stabilize interactions of proteins with membranes and with other proteins

Topics: Biological Sciences
Publisher: The National Academy of Sciences
Year: 2000
OAI identifier:
Provided by: PubMed Central
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